TBX1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TBX1 mutation is significantly associated with the RNA expression of many other genes, with 924 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX1-associated genes across cancer lineages are TCERG1L-AS1, RNA5SP410, and LINC02558. Each is linked with TBX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBX1-to-partner and partner-to-TBX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX1→partner) and Y-score (partner→TBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECTCERG1L-AS1 →+0.255+2.063<.001.00133
LGGRNA5SP410 →+0.312+7.977<.001.00732
LUSCLINC02558 →+0.212+3.650<.001.00632
UCECRNY1P1 →+0.150+2.920.003.00832
UCECRNA5SP372 →+0.405+2.189.004.00232
SKCMMIR1289-1 →+0.302+3.050.006.00832
Each partner links to its Q-omics profile. Showing the 6 strongest of 924 associations by consensus.

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