Across TCGA patient cohorts, TBX1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX1-associated genes across cancer lineages are JNK2, PCNA, and PDK1_pS241. Each is linked with TBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX1-to-partner and partner-to-TBX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX1→partner) and Y-score (partner→TBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.257	+2.807	.003	.003	3	2
UCEC	PCNA →	+0.250	+3.169	.008	.018	3	2
UCEC	PDK1_pS241 →	+0.194	+2.820	.009	.001	3	2
UCEC	TIGAR →	+0.168	+2.999	.011	.035	3	2
UCEC	4E-BP1 →	+0.413	+2.351	<.001	.018	3	2
UCEC	eIF4E →	+0.215	+3.013	.019	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

TBX1 survival (RNA) · tumor vs normal (RNA) · all TBX1 data types