Across TCGA cell cohorts, TBX1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TBX1-associated genes across cancer lineages are AVP, ETDC, and PRM3. Each is linked with TBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX1-to-partner and partner-to-TBX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX1→partner) and Y-score (partner→TBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	ETDC →	+0.556	+5.209	<.001	.005	3	1
CNS	PRM3 →	+0.178	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

TBX1 survival (RNA) · tumor vs normal (RNA) · all TBX1 data types