TBRG1

Across TCGA patient cohorts, TBRG1 mutation is significantly associated with the RNA expression of many other genes, with 137 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBRG1-associated genes across cancer lineages are SPATA31A5, MIR216A, and RNU6-1242P. Each is linked with TBRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBRG1-to-partner and partner-to-TBRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31A5 grouped by TBRG1-low versus TBRG1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBRG1→partner) and Y-score (partner→TBRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPATA31A5 →	+0.004	+8.471	<.001	.005	3	1
BRCA	MIR216A →	+0.234	+7.731	<.001	.009	3	1
COAD	RNU6-1242P →	+1.096	+5.017	<.001	.009	3	1
UCEC	SUMO2P15 →	+0.400	+2.455	<.001	.007	3	1
UCEC	SUGT1-DT →	+0.572	+3.210	.009	.009	3	1
UCEC	RNA5SP411 →	+1.142	+2.656	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 137 associations by consensus.

SPATA31A5 by TBRG1 expression — BRCA

Explore this box plot interactively →