TBRG1

Across TCGA patient cohorts, TBRG1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBRG1-associated genes across cancer lineages are Gab2, MEK1, and Tuberin. Each is linked with TBRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBRG1-to-partner and partner-to-TBRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by TBRG1-low versus TBRG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBRG1→partner) and Y-score (partner→TBRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.653	+3.000	.001	.037	3	1
UCEC	MEK1 →	+0.483	+3.000	.022	.037	3	1
UCEC	Tuberin →	+0.329	+3.000	.034	.037	3	1
UCEC	VEGFR2 →	+0.497	+2.817	.003	.036	3	1
UCEC	Chk2 →	-0.367	-3.000	.006	.037	3	1
UCEC	STAT5a →	+0.477	+3.000	.039	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Gab2 by TBRG1 expression — UCEC

Explore this box plot interactively →