TBR1

Across TCGA patient cohorts, TBR1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,732 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TBR1-associated genes across cancer lineages are PNPLA5, CACNA1I, and CHGA. Each is linked with TBR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBR1-to-partner and partner-to-TBR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TBR1 versus PNPLA5 in GBM, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBR1→partner) and Y-score (partner→TBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PNPLA5 →	+0.199	+0.317	<.001	<.001	3	1
GBM	CACNA1I →	+0.745	+0.506	<.001	<.001	3	1
GBM	CHGA →	+1.793	+0.433	<.001	.001	3	1
GBM	CPNE6 →	+0.896	+0.366	.001	.007	3	1
GBM	SGK2 →	+0.433	+0.258	.004	.005	3	1
GBM	HRH3 →	+0.808	+0.434	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,732 associations by consensus.

TBR1 vs PNPLA5 — GBM

Explore this scatter interactively →