TBR1

Across TCGA patient cohorts, TBR1 mutation is significantly associated with the RNA expression of many other genes, with 3,108 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBR1-associated genes across cancer lineages are PEDS1-UBE2V1, DPP9, and RPS15AP34. Each is linked with TBR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBR1-to-partner and partner-to-TBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEDS1-UBE2V1 grouped by TBR1-low versus TBR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBR1→partner) and Y-score (partner→TBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEDS1-UBE2V1 →	+0.022	+1.818	.001	.002	3	3
UCEC	DPP9 →	+0.467	+2.769	<.001	<.001	3	3
COAD	RPS15AP34 →	+0.317	+2.769	<.001	.004	3	3
SKCM	MTCO1P52 →	+0.026	+4.485	<.001	.004	3	3
LGG	TTTY7 →	+0.024	+7.977	<.001	.007	3	2
UCEC	CASTOR2 →	+0.652	+2.769	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,108 associations by consensus.

PEDS1-UBE2V1 by TBR1 expression — UCEC

Explore this box plot interactively →