TBR1

Across TCGA patient cohorts, TBR1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBR1-associated genes across cancer lineages are eEF2, ERK2, and GAPDH. Each is linked with TBR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBR1-to-partner and partner-to-TBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TBR1-low versus TBR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBR1→partner) and Y-score (partner→TBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.384	+1.906	.007	.016	3	2
UCEC	ERK2 →	+0.210	+2.459	.006	.018	3	2
UCEC	GAPDH →	+0.488	+3.169	.023	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.194	-2.321	.004	.033	3	2
UCEC	NF2 →	+0.240	+2.459	.005	.019	3	2
UCEC	PCNA →	+0.205	+2.115	.018	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eEF2 by TBR1 expression — UCEC

Explore this box plot interactively →