TBR1

Across TCGA cell cohorts, TBR1 mutation is significantly associated with the mutation status of many other genes, with 5,349 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBR1-associated genes across cancer lineages are ZBTB20, FIGN, and CTTNBP2. Each is linked with TBR1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TBR1-to-partner and partner-to-TBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB20 grouped by TBR1-low versus TBR1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBR1→partner) and Y-score (partner→TBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZBTB20 →	+5.044	+5.614	.003	.003	1	6
STOMACH	FIGN →	+3.357	+4.285	.005	.005	1	6
CNS	CTTNBP2 →	+4.459	+5.277	.005	.005	1	6
UPPER_AERODIGESTIVE_TRACT	MPDZ →	+4.392	+4.954	.008	.008	1	6
BLOOD_Leukemia	DOCK4 →	+2.975	+3.794	.006	.006	1	6
CNS	SMARCC1 →	+6.044	+6.044	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,349 associations by consensus.

ZBTB20 by TBR1 expression — CNS

Explore this box plot interactively →