TBPL2

Across TCGA patient cohorts, TBPL2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBPL2-associated genes across cancer lineages are mTOR_pS2448, TFRC, and eIF4E. Each is linked with TBPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBPL2-to-partner and partner-to-TBPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TBPL2-low versus TBPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBPL2→partner) and Y-score (partner→TBPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.166	-2.700	.013	.006	3	2
UCEC	TFRC →	+0.616	+3.169	.010	.019	3	2
UCEC	eIF4E →	+0.279	+3.459	.003	.005	2	2
UCEC	FOXO3a_pS318_S321 →	-0.118	-2.449	.036	.019	3	1
UCEC	GATA6 →	-0.160	-2.693	.021	.006	3	1
UCEC	IRS1 →	-0.222	-2.000	.017	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

mTOR_pS2448 by TBPL2 expression — UCEC

Explore this box plot interactively →