TBPL2

Across TCGA cell cohorts, TBPL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 778 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TBPL2-associated GO terms across cancer lineages are Protein targeting to lysosome, Regulation of pattern recognition receptor signaling pathway, and Negative regulation of myoblast fusion. Each is linked with TBPL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TBPL2-to-partner and partner-to-TBPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to lysosome grouped by TBPL2-low versus TBPL2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBPL2→partner) and Y-score (partner→TBPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Protein targeting to lysosome →	+0.051	+0.057	.005	.004	3	4
BLOOD_Lymphoma	Regulation of pattern recognition receptor signaling pathway →	+0.039	+0.034	<.001	.002	3	4
BONE	Negative regulation of myoblast fusion →	+0.081	+0.075	.001	.007	3	4
BONE	Regulation of type I interferon production →	+0.056	+0.062	<.001	.005	2	5
BONE	Detection of external stimulus →	-0.075	-0.087	.005	.001	3	4
LUNG_NSCLC_LUAD	Response to type I interferon →	+0.052	+0.060	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 778 associations by consensus.

Protein targeting to lysosome by TBPL2 expression — LUNG_NSCLC_LUAD

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