TBPL2

Across TCGA cell cohorts, TBPL2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TBPL2-associated genes across cancer lineages are KIR3DL1 and SCGB1C1. Each is linked with TBPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBPL2-to-partner and partner-to-TBPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR3DL1 grouped by TBPL2-low versus TBPL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBPL2→partner) and Y-score (partner→TBPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KIR3DL1 →	+0.016	+4.977	<.001	.007	3	1
BREAST	SCGB1C1 →	+0.067	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

KIR3DL1 by TBPL2 expression — LARGE_INTESTINE

Explore this box plot interactively →