TBPL1

Across TCGA patient cohorts, TBPL1 mutation is significantly associated with the RNA expression of many other genes, with 1,405 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBPL1-associated genes across cancer lineages are RPL32P8, MIR3135A, and RNU4-45P. Each is linked with TBPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBPL1-to-partner and partner-to-TBPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL32P8 grouped by TBPL1-low versus TBPL1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBPL1→partner) and Y-score (partner→TBPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPL32P8 →	+0.173	+3.684	<.001	.005	3	2
CESC	MIR3135A →	+0.486	+3.918	<.001	.001	3	2
CESC	RNU4-45P →	+0.145	+4.342	<.001	.007	3	1
CESC	MIR549A →	+0.220	+4.342	<.001	.007	3	1
CESC	TRBV10-1 →	+0.613	+3.692	<.001	.007	3	1
CESC	TRAJ12 →	+0.540	+3.608	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,405 associations by consensus.

RPL32P8 by TBPL1 expression — CESC

Explore this box plot interactively →