TBP

Across TCGA pan-cancer cohorts, TBP mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TBP data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TBP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TBP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where TBP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.787	0.243	.001	14	view →
HNSC	DFS	Tertile	All	0.153	0.949	.038	12	view →
LSCC	OS	Quartile	All	0.921	0.704	.019	3	view →
UCEC	OS	Median	All	0.910	0.984	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TBP–CCRCC (DFS)

Open the CCRCC breakdown →