TBL3

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TBL3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBL3-associated genes across cancer lineages are PCNA, PDCD4, and Caspase-7-cleavedD198. Each is linked with TBL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBL3-to-partner and partner-to-TBL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBL3→partner) and Y-score (partner→TBL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPCNA →+0.209+2.087.008.00532
UCECPDCD4 →-0.439-3.169.011.01832
UCECCaspase-7-cleavedD198 →+0.913+3.700<.001.00132
UCEC4E-BP1 →+0.303+3.169.002.01832
UCECCyclin-B1 →+0.496+3.169.016.01832
SKCMp90 RSK →+0.206+3.000.024.03432
Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration