Across TCGA cell cohorts, TBL3 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBL3-associated genes across cancer lineages are GML, OTOP1, and NTSR2. Each is linked with TBL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBL3-to-partner and partner-to-TBL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBL3→partner) and Y-score (partner→TBL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.056	+2.982	<.001	.007	3	2
URINARY_TRACT	OTOP1 →	+0.210	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	NTSR2 →	+0.569	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR11H1 →	+0.022	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2W1 →	+0.032	+4.662	<.001	.005	3	1
BLOOD_Leukemia	VSX1 →	+0.323	+4.083	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

Exploration

TBL3 survival (RNA) · tumor vs normal (RNA) · all TBL3 data types