TBL2

Across TCGA patient cohorts, TBL2 mutation is significantly associated with the RNA expression of many other genes, with 3,644 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBL2-associated genes across cancer lineages are MIR8087, C11orf54, and ZNF527. Each is linked with TBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBL2-to-partner and partner-to-TBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8087 grouped by TBL2-low versus TBL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBL2→partner) and Y-score (partner→TBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR8087 →	+0.446	+2.894	<.001	.003	3	3
UCEC	C11orf54 →	+0.503	+3.202	.005	.009	3	2
UCEC	ZNF527 →	+0.428	+3.732	<.001	<.001	3	2
UCEC	ZNF431 →	+0.495	+2.276	.002	.005	3	2
UCEC	FAR1 →	+0.593	+2.595	.005	.005	3	2
LUSC	MIR150 →	+0.375	+4.031	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,644 associations by consensus.

MIR8087 by TBL2 expression — SKCM

Explore this box plot interactively →