TBL2

Across TCGA cell cohorts, TBL2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBL2-associated genes across cancer lineages are PRSS54, RHOXF2, and FAM205A. Each is linked with TBL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBL2-to-partner and partner-to-TBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by TBL2-low versus TBL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBL2→partner) and Y-score (partner→TBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.038	+3.345	<.001	.007	3	1
LARGE_INTESTINE	RHOXF2 →	+0.043	+3.544	<.001	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.022	+4.614	<.001	.002	3	1
BLOOD_Leukemia	GPR101 →	+0.089	+3.966	<.001	.001	3	1
BLOOD_Leukemia	OR10V1 →	+0.023	+4.569	<.001	.003	3	1
BLOOD_Leukemia	GSG1L2 →	+0.028	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PRSS54 by TBL2 expression — LARGE_INTESTINE

Explore this box plot interactively →