TBL2

Across TCGA cell cohorts, TBL2 mutation is significantly associated with the mutation status of many other genes, with 3,889 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBL2-associated genes across cancer lineages are SLC39A13, ZC3H6, and GRIK5. Each is linked with TBL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBL2-to-partner and partner-to-TBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC39A13 grouped by TBL2-low versus TBL2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBL2→partner) and Y-score (partner→TBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SLC39A13 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	ZC3H6 →	+4.392	+4.954	.008	.008	1	4
CNS	GRIK5 →	+4.459	+5.277	.005	.005	1	4
LARGE_INTESTINE	EXOC7 →	+3.874	+4.215	<.001	<.001	1	4
BLOOD_Leukemia	CHRNB1 →	+4.247	+3.560	.002	.002	1	4
BLOOD_Leukemia	GREB1 →	+3.662	+4.209	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,889 associations by consensus.

SLC39A13 by TBL2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →