TBL1Y

Across TCGA patient cohorts, TBL1Y mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TBL1Y-associated genes across cancer lineages are RN7SL711P, OR2BH1P, and RPL3P13. Each is linked with TBL1Y in more than 1 cancer types. Because this analysis shows association rather than direction, both TBL1Y-to-partner and partner-to-TBL1Y results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL711P grouped by TBL1Y-low versus TBL1Y-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBL1Y→partner) and Y-score (partner→TBL1Y) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL711P →	+0.323	+3.849	<.001	.008	3	2
SKCM	OR2BH1P →	+0.029	+5.810	<.001	<.001	3	2
SKCM	RPL3P13 →	+0.234	+3.526	<.001	.005	3	1
SKCM	PSMB7P1 →	+0.045	+4.469	<.001	.006	3	1
LUSC	OR2V1 →	+0.261	+3.884	<.001	.006	3	1
LUSC	RNU6-784P →	+0.394	+4.070	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

RN7SL711P by TBL1Y expression — LUSC

Explore this box plot interactively →