TBL1XR1

Across TCGA pan-cancer cohorts, TBL1XR1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TBL1XR1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TBL1XR1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TBL1XR1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where TBL1XR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.587	0.856	.002	40	view →
GBM	OS	Quartile	All	0.595	0.282	<.001	13	view →
CCRCC	OS	Quartile	All	0.767	0.960	.023	3	view →
LUAD	OS	Quartile	All	0.970	0.800	.034	3	view →
UCEC	OS	Tertile	All	0.936	1.000	.049	2	view →
PDAC	OS	Quartile	All	0.441	0.662	.041	2	view →
LSCC	OS	Median	All	0.845	0.915	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TBL1XR1–HNSC (OS)

Open the HNSC breakdown →