TBL1X

Across TCGA pan-cancer cohorts, TBL1X mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TBL1X data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TBL1X mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TBL1X expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where TBL1X mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	48	view →
PDAC	OS	Quartile	All	0.981	0.840	.024	8	view →
LSCC	DFS	Quartile	II,III,IV	0.248	0.858	.017	3	view →
HNSC	DFS	Median	III,IV	0.939	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TBL1X–UCEC (OS)

Open the UCEC breakdown →