Across TCGA pan-cancer cohorts, TBKBP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TBKBP1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TBKBP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBKBP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

GBM, HNSC, and LUAD are the cancer types where TBKBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.325	0.920	.006	19	view →
HNSC	DFS	Tertile	II,III,IV	0.775	1.000	.044	4	view →
LUAD	OS	Tertile	III,IV	0.845	0.229	.035	2	view →
CCRCC	DFS	Median	All	0.917	0.616	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TBKBP1 tumor-vs-normal RNA expression · all TBKBP1 data types