Across TCGA patient cohorts, TBKBP1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBKBP1-associated genes across cancer lineages are ATM, A-Raf_pS299, and ERK2. Each is linked with TBKBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBKBP1-to-partner and partner-to-TBKBP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBKBP1→partner) and Y-score (partner→TBKBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.515	-2.446	.001	.018	3	2
UCEC	A-Raf_pS299 →	-0.124	-2.459	.003	.018	3	1
UCEC	ERK2 →	+0.216	+2.584	.001	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.125	-2.807	.005	.002	3	1
UCEC	GAPDH →	+0.384	+1.874	.047	.049	3	1
UCEC	HER3_pY1289 →	+0.064	+1.926	.039	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

TBKBP1 survival (RNA) · tumor vs normal (RNA) · all TBKBP1 data types