Across TCGA cell cohorts, TBKBP1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBKBP1-associated genes across cancer lineages are TBPL2, DEFB108B, and OR10R2. Each is linked with TBKBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBKBP1-to-partner and partner-to-TBKBP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBKBP1→partner) and Y-score (partner→TBKBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TBPL2 →	+0.075	+4.044	.001	.004	3	1
BLOOD_Leukemia	DEFB108B →	+0.127	+4.269	<.001	.002	3	1
BLOOD_Leukemia	OR10R2 →	+1.568	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

TBKBP1 survival (RNA) · tumor vs normal (RNA) · all TBKBP1 data types