Across TCGA pan-cancer cohorts, TBK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TBK1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TBK1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TBK1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where TBK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.669	1.000	.003	23	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →
LUAD	DFS	Median	All	0.914	0.887	.029	3	view →
HNSC	OS	Quartile	IV	0.807	0.548	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TBK1 tumor-vs-normal RNA expression · all TBK1 data types