Across TCGA patient cohorts, TBK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,488 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TBK1-associated proteins across cancer lineages are MYG1, HSP90AB1, and TIMM23. Each is linked with TBK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TBK1-to-partner and partner-to-TBK1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TBK1→partner) and Y-score (partner→TBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MYG1 →	+0.347	+0.352	<.001	<.001	3	5
CCRCC	HSP90AB1 →	+0.233	+0.286	<.001	<.001	3	4
BRCA	TIMM23 →	-0.381	-0.447	.002	<.001	3	3
PDAC	TXNDC9 →	+0.183	+0.232	.009	.006	3	3
UCEC	ORC6_T195 →	+0.909	+0.310	<.001	.004	3	3
BRCA	RSL1D1_S361 →	-1.032	-0.527	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,488 associations by consensus.

Exploration

TBK1 survival (RNA) · tumor vs normal (RNA) · all TBK1 data types