Across TCGA patient cohorts, TBK1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,225 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible TBK1-associated genes across cancer lineages are GALNT18, DOK3, and ZNF683. Each is linked with TBK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TBK1-to-partner and partner-to-TBK1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBK1→partner) and Y-score (partner→TBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GALNT18 →	-0.851	-0.133	<.001	.001	3	4
HNSC	DOK3 →	+0.576	+0.155	.002	<.001	3	4
HNSC	ZNF683 →	+0.908	+0.124	<.001	.004	3	4
HNSC	LILRB4 →	+0.886	+0.118	<.001	.001	2	5
GBM	PSAP →	+0.534	+0.118	<.001	<.001	3	4
LSCC	FBXO34 →	-0.476	-0.130	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,225 associations by consensus.

Exploration

TBK1 survival (RNA) · tumor vs normal (RNA) · all TBK1 data types