Across TCGA patient cohorts, TBK1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBK1-associated genes across cancer lineages are STAT3_pY705, S6_pS240_S244, and ASNS. Each is linked with TBK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBK1-to-partner and partner-to-TBK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBK1→partner) and Y-score (partner→TBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.376	-2.070	<.001	.001	3	2
UCEC	S6_pS240_S244 →	+0.302	+2.183	.032	.033	3	2
UCEC	ASNS →	+0.446	+2.070	<.001	.001	3	2
UCEC	CDK1 →	+0.142	+2.321	.006	.005	3	2
UCEC	C-Raf →	+0.193	+2.169	<.001	.003	3	2
UCEC	Cyclin-B1 →	+0.788	+2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

TBK1 survival (RNA) · tumor vs normal (RNA) · all TBK1 data types