Across TCGA cell cohorts, TBK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,498 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TBK1-associated GO terms across cancer lineages are Regulation of protein acetylation, Positive regulation of organelle assembly, and Protein targeting to vacuole. Each is linked with TBK1 in more than 11 cancer types. Because this analysis shows association rather than direction, both TBK1-to-partner and partner-to-TBK1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBK1→partner) and Y-score (partner→TBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of protein acetylation →	+0.105	+0.578	.002	.006	3	12
BREAST	Positive regulation of organelle assembly →	+0.066	+0.826	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Protein targeting to vacuole →	+0.066	+0.722	<.001	.002	3	12
LUNG_SCLC	Regulation of centrosome duplication →	+0.097	+0.471	.001	.007	3	11
STOMACH	Regulation of centriole replication →	+0.081	+0.610	<.001	<.001	3	11
BLOOD_Lymphoma	DNA damage tolerance →	+0.075	+0.863	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,498 associations by consensus.

Exploration

TBK1 survival (RNA) · tumor vs normal (RNA) · all TBK1 data types