Across TCGA cell cohorts, TBK1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TBK1-associated genes across cancer lineages are OR56A5, BPIFA2, and CPLX4. Each is linked with TBK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBK1-to-partner and partner-to-TBK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBK1→partner) and Y-score (partner→TBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR56A5 →	+0.066	+4.887	<.001	.009	3	3
BLOOD_Myeloma	BPIFA2 →	+0.020	+4.807	<.001	.006	3	1
LARGE_INTESTINE	CPLX4 →	+0.025	+3.766	.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1
LUNG_SCLC	PRAMEF11 →	+0.026	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	FAM24A →	+0.055	+5.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

TBK1 survival (RNA) · tumor vs normal (RNA) · all TBK1 data types