TBCK

Across TCGA pan-cancer cohorts, TBCK Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TBCK data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher TBCK Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TBCK expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCS, OV, and UCEC are the cancer types where TBCK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.001	0.690	<.001	36	view →
OV	OS	Median	II,III,IV	0.021	0.844	<.001	36	view →
UCEC	DFS	Median	All	0.974	0.826	.009	28	view →
BLCA	OS	Median	II,III,IV	1.000	0.410	.028	11	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TBCK–UCS (OS)

Open the UCS breakdown →