TBCK

Across TCGA cell cohorts, TBCK mutation is significantly associated with the RNA expression of many other genes, with 1,576 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBCK-associated genes across cancer lineages are OR2B2, PXYLP1, and KCNJ11. Each is linked with TBCK in more than 1 cancer types. Because this analysis shows association rather than direction, both TBCK-to-partner and partner-to-TBCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2B2 grouped by TBCK-low versus TBCK-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBCK→partner) and Y-score (partner→TBCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR2B2 →	+0.036	+5.000	<.001	.005	3	2
LARGE_INTESTINE	PXYLP1 →	+0.704	+2.389	.002	.006	3	2
LARGE_INTESTINE	KCNJ11 →	+0.622	+2.043	.005	.008	3	2
LARGE_INTESTINE	ADAM22 →	+0.729	+2.043	.001	.008	3	2
BLOOD_Leukemia	R3HDML →	+0.010	+3.984	<.001	.006	3	1
BLOOD_Leukemia	RLN1 →	+0.356	+4.003	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,576 associations by consensus.

OR2B2 by TBCK expression — KIDNEY

Explore this box plot interactively →