TBCD

Across TCGA pan-cancer cohorts, TBCD mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TBCD’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TBCD mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TBCD is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where TBCD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBCD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.350	<.001	12	view →
HNSC	All	IV	+0.189	.003	8	view →
COAD	Female	II,III,IV	+0.118	<.001	6	view →
LUAD	Male	All	+0.158	<.001	5	view →
LSCC	Male	All	+0.126	.002	4	view →
PDAC	Female	All	−0.138	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TBCD–CCRCC

Open the CCRCC breakdown →