TBCD

Across TCGA patient cohorts, TBCD mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBCD-associated genes across cancer lineages are ATM, Chk2, and Mre11. Each is linked with TBCD in more than 3 cancer types. Because this analysis shows association rather than direction, both TBCD-to-partner and partner-to-TBCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TBCD-low versus TBCD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBCD→partner) and Y-score (partner→TBCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.428	-1.925	.001	.004	3	4
BLCA	Chk2 →	+0.327	+3.000	.002	.034	3	2
COAD	Mre11 →	+0.212	+3.008	<.001	.019	3	2
COAD	PKC-b-II_pS660 →	-0.520	-2.991	.004	.036	3	2
COAD	TSC1 →	-0.605	-2.991	<.001	.036	3	2
COAD	Tuberin →	-0.581	-2.991	<.001	.036	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ATM by TBCD expression — UCEC

Explore this box plot interactively →