TBCD

Across TCGA cell cohorts, TBCD mutation is significantly associated with the RNA expression of many other genes, with 422 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBCD-associated genes across cancer lineages are C4orf50, PRAMEF9, and IAPP. Each is linked with TBCD in more than 1 cancer types. Because this analysis shows association rather than direction, both TBCD-to-partner and partner-to-TBCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf50 grouped by TBCD-low versus TBCD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBCD→partner) and Y-score (partner→TBCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C4orf50 →	+0.263	+3.974	<.001	.002	3	2
URINARY_TRACT	PRAMEF9 →	+0.013	+5.087	<.001	.004	3	1
CNS	IAPP →	+0.146	+3.774	<.001	.008	3	1
CNS	OR10G7 →	+0.008	+4.772	<.001	.002	3	1
CNS	C2CD4B →	+0.030	+4.044	.002	.003	3	1
CNS	CFHR2 →	+0.046	+4.772	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 422 associations by consensus.

C4orf50 by TBCD expression — BLOOD_Leukemia

Explore this box plot interactively →