TBCCD1

Across TCGA pan-cancer cohorts, TBCCD1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TBCCD1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TBCCD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBCCD1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where TBCCD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBCCD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.079	<.001	12	view →
THCA	All	II,III,IV	−0.496	<.001	10	view →
LIHC	All	III,IV	+0.771	<.001	9	view →
BLCA	All	All	+0.739	<.001	9	view →
LUSC	Female	All	+1.424	<.001	8	view →
KICH	Female	All	−1.122	<.001	8	view →
STAD	All	II,III,IV	+0.593	<.001	6	view →
COAD	All	All	+0.327	<.001	6	view →
CHOL	Male	All	+1.343	<.001	5	view →
ESCA	All	All	+0.659	.003	4	view →
BRCA	All	II,III,IV	+0.255	<.001	4	view →
UCEC	All	II,III,IV	+0.702	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TBCCD1–HNSC

Open the HNSC breakdown →