TBCA

Across TCGA pan-cancer cohorts, TBCA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TBCA data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TBCA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBCA expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where TBCA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.519	0.878	.002	26	view →
PDAC	DFS	Tertile	All	0.698	0.963	<.001	11	view →
LSCC	OS	Median	III,IV	0.506	0.863	.011	6	view →
UCEC	OS	Tertile	III,IV	1.000	0.484	.049	4	view →
HNSC	DFS	Median	IV	1.000	0.927	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TBCA–CCRCC (DFS)

Open the CCRCC breakdown →