TBC1D7

Across TCGA pan-cancer cohorts, TBC1D7 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TBC1D7 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TBC1D7 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TBC1D7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where TBC1D7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.844	0.454	<.001	74	view →
UCEC	OS	Quartile	All	1.000	0.822	.012	20	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.547	.007	12	view →
PDAC	DFS	Median	III,IV	0.203	0.566	.020	4	view →
LUAD	OS	Median	All	0.681	0.855	.016	3	view →
GBM	OS	Median	All	0.879	0.758	.038	1	view →
LSCC	DFS	Tertile	All	0.803	0.606	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TBC1D7–HNSC (DFS)

Open the HNSC breakdown →