TBC1D5

Across TCGA patient cohorts, TBC1D5 mutation is significantly associated with the RNA expression of many other genes, with 4,301 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D5-associated genes across cancer lineages are FEN1, HGS, and CACTIN. Each is linked with TBC1D5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D5-to-partner and partner-to-TBC1D5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEN1 grouped by TBC1D5-low versus TBC1D5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D5→partner) and Y-score (partner→TBC1D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FEN1 →	+0.687	+2.676	<.001	<.001	3	3
SKCM	HGS →	+0.403	+4.019	.006	<.001	3	3
UCEC	CACTIN →	+0.477	+3.126	<.001	<.001	3	3
UCEC	ZBTB17 →	+0.306	+1.896	.005	.004	3	3
UCEC	ZWINT →	+0.846	+2.643	<.001	<.001	3	3
UCEC	FOXK2 →	+0.331	+2.305	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,301 associations by consensus.

FEN1 by TBC1D5 expression — UCEC

Explore this box plot interactively →