TBC1D5

Across TCGA patient cohorts, TBC1D5 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D5-associated genes across cancer lineages are ERK2, FoxM1, and MEK1. Each is linked with TBC1D5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D5-to-partner and partner-to-TBC1D5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TBC1D5-low versus TBC1D5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D5→partner) and Y-score (partner→TBC1D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.142	+2.459	.041	.018	3	2
UCEC	FoxM1 →	+0.193	+3.321	.038	.009	3	2
UCEC	MEK1 →	+0.458	+2.807	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.110	-1.680	.041	.042	3	2
UCEC	Rictor_pT1135 →	-0.076	-1.584	.040	.019	3	2
UCEC	ATM →	-0.665	-1.925	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ERK2 by TBC1D5 expression — UCEC

Explore this box plot interactively →