TBC1D5

Across TCGA cell cohorts, TBC1D5 mutation is significantly associated with the RNA expression of many other genes, with 227 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D5-associated genes across cancer lineages are ABCG4, ESX1, and KRTAP9-3. Each is linked with TBC1D5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D5-to-partner and partner-to-TBC1D5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCG4 grouped by TBC1D5-low versus TBC1D5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D5→partner) and Y-score (partner→TBC1D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ABCG4 →	+0.289	+3.866	<.001	<.001	3	2
BLOOD_Myeloma	ESX1 →	+0.126	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP9-3 →	+0.033	+4.807	<.001	.006	3	1
SKIN	POTEB3 →	+0.043	+4.095	<.001	.009	3	1
BLOOD_Leukemia	CGB2 →	+0.563	+3.234	.005	.008	3	1
BLOOD_Leukemia	GHRHR →	+0.358	+4.121	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 227 associations by consensus.

ABCG4 by TBC1D5 expression — LARGE_INTESTINE

Explore this box plot interactively →