TBC1D4

Across TCGA patient cohorts, TBC1D4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,932 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TBC1D4-associated proteins across cancer lineages are TBC1D4_S666, ARHGEF7, and TBC1D4_S106. Each is linked with TBC1D4 in more than 6 cancer types. Because this analysis shows association rather than direction, both TBC1D4-to-partner and partner-to-TBC1D4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TBC1D4 versus TBC1D4_S666 in HNSC, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D4→partner) and Y-score (partner→TBC1D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TBC1D4_S666 →	+0.831	+0.727	<.001	<.001	3	7
LSCC	ARHGEF7 →	+0.188	+0.658	.001	<.001	3	5
UCEC	TBC1D4_S106 →	+1.346	+1.305	<.001	<.001	3	5
LSCC	TBC1D4_S570 →	+1.272	+0.808	<.001	<.001	3	5
HNSC	TBC1D4_S588 →	+0.948	+0.676	<.001	<.001	2	6
CCRCC	TBC1D4_S591 →	+1.325	+1.031	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,932 associations by consensus.

TBC1D4 vs TBC1D4_S666 — HNSC

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