TBC1D4

Across TCGA patient cohorts, TBC1D4 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D4-associated genes across cancer lineages are eIF4E, Smad4, and HER3_pY1289. Each is linked with TBC1D4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D4-to-partner and partner-to-TBC1D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TBC1D4-low versus TBC1D4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D4→partner) and Y-score (partner→TBC1D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.126	+2.235	.031	.005	3	3
COAD	Smad4 →	+0.136	+2.178	.029	.035	3	3
STAD	HER3_pY1289 →	+0.117	+2.480	.002	.010	3	2
STAD	STAT5a →	-0.610	-3.000	.020	.033	3	2
UCEC	EGFR_pY1068 →	-0.165	-1.000	.018	.033	3	2
UCEC	FoxM1 →	+0.217	+1.678	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

eIF4E by TBC1D4 expression — UCEC

Explore this box plot interactively →