TBC1D4

Across TCGA cell cohorts, TBC1D4 mutation is significantly associated with the RNA expression of many other genes, with 712 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D4-associated genes across cancer lineages are OR5A1, ALKBH7, and ABHD6. Each is linked with TBC1D4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D4-to-partner and partner-to-TBC1D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5A1 grouped by TBC1D4-low versus TBC1D4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D4→partner) and Y-score (partner→TBC1D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR5A1 →	+1.028	+4.981	<.001	.008	3	2
BLOOD_Leukemia	ALKBH7 →	+0.388	+2.614	.006	.003	3	2
BLOOD_Leukemia	ABHD6 →	+0.875	+2.674	<.001	.003	3	2
LARGE_INTESTINE	ADPRS →	+0.452	+3.295	.001	.003	3	2
LARGE_INTESTINE	PHF10 →	+0.639	+3.169	.005	.009	3	2
LARGE_INTESTINE	RAB28 →	+0.498	+2.502	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 712 associations by consensus.

OR5A1 by TBC1D4 expression — CNS

Explore this box plot interactively →