TBC1D3P5

Across TCGA patient cohorts, TBC1D3P5 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D3P5-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with TBC1D3P5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D3P5-to-partner and partner-to-TBC1D3P5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TBC1D3P5-low versus TBC1D3P5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D3P5→partner) and Y-score (partner→TBC1D3P5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.266	+2.000	.035	.029	3	1
UCEC	EGFR_pY1068 →	-0.258	-2.000	.003	.003	3	1
UCEC	eIF4E →	+0.169	+3.335	.023	.005	3	1
UCEC	A-Raf_pS299 →	-0.132	-2.222	.001	.010	3	1
UCEC	ERK2 →	+0.210	+3.700	.001	.001	3	1
UCEC	GATA6 →	-0.121	-3.155	.037	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by TBC1D3P5 expression — UCEC

Explore this box plot interactively →