TBC1D32

Across TCGA patient cohorts, TBC1D32 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D32-associated genes across cancer lineages are Shc_pY317, FoxM1, and MEK1. Each is linked with TBC1D32 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D32-to-partner and partner-to-TBC1D32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by TBC1D32-low versus TBC1D32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D32→partner) and Y-score (partner→TBC1D32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.180	-2.321	<.001	<.001	3	3
UCEC	FoxM1 →	+0.170	+1.459	.043	.012	3	2
UCEC	MEK1 →	+0.384	+2.247	.001	.001	3	2
UCEC	S6_pS240_S244 →	+0.307	+2.459	.020	.019	3	2
UCEC	STAT3_pY705 →	-0.389	-2.502	<.001	.001	3	2
UCEC	TIGAR →	+0.154	+1.248	.001	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Shc_pY317 by TBC1D32 expression — UCEC

Explore this box plot interactively →