TBC1D30

Across TCGA patient cohorts, TBC1D30 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D30-associated genes across cancer lineages are HER3, p62 Lck ligand, and P-Cadherin. Each is linked with TBC1D30 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D30-to-partner and partner-to-TBC1D30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by TBC1D30-low versus TBC1D30-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D30→partner) and Y-score (partner→TBC1D30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	+0.414	+2.820	.001	.035	3	1
UCEC	p62 Lck ligand →	+0.423	+2.584	.005	.011	3	1
UCEC	P-Cadherin →	-0.164	-2.999	.014	.035	3	1
UCEC	STAT3_pY705 →	-0.554	-3.700	<.001	.001	3	1
UCEC	C-Raf →	+0.222	+3.000	<.001	.036	3	1
UCEC	Di-Ras3 →	-0.197	-2.584	.004	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

HER3 by TBC1D30 expression — UCEC

Explore this box plot interactively →