TBC1D25

Across TCGA pan-cancer cohorts, TBC1D25 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TBC1D25 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TBC1D25 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D25 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

LUAD, HNSC, and GBM are the cancer types where TBC1D25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.473	0.740	.004	24	view →
HNSC	DFS	Quartile	IV	1.000	0.491	.033	5	view →
GBM	DFS	Tertile	All	0.797	0.653	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TBC1D25–LUAD (DFS)

Open the LUAD breakdown →