TBC1D25

Across TCGA patient cohorts, TBC1D25 mutation is significantly associated with the RNA expression of many other genes, with 2,527 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D25-associated genes across cancer lineages are OTULIN, FBXO22, and CCDC134. Each is linked with TBC1D25 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D25-to-partner and partner-to-TBC1D25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTULIN grouped by TBC1D25-low versus TBC1D25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D25→partner) and Y-score (partner→TBC1D25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OTULIN →	+0.365	+1.595	<.001	<.001	3	3
COAD	FBXO22 →	+0.407	+3.479	<.001	.002	3	3
UCEC	CCDC134 →	+0.311	+1.617	.007	.009	3	2
UCEC	HMOX1 →	+0.630	+1.716	<.001	.001	3	2
UCEC	APOBEC3H →	+0.363	+1.890	.002	.004	3	2
UCEC	IL2RB →	+0.744	+2.258	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,527 associations by consensus.

OTULIN by TBC1D25 expression — UCEC

Explore this box plot interactively →